Endocrine Abstracts

Background: Alongside various physical symptoms, patients with high levels of cortisol, such as typically found in Cushing’s disease, often display a wide variety of neuropsychiatric symptoms such as depression, psychosis, mania and cognitive impairments. This indicates involvement of the central nervous system in hypercortisolism.Methods: Various neuroimaging approaches can be used to examine the effects of hypercortisolism on the brain. The freque...

Background: Patients with long-term remission of Cushing’s disease (CD) demonstrate residual psychological complaints. At present, it is not known how previous exposure to hypercortisolism affects psychological functioning in the long-term. In foregoing Magnetic Resonance Imaging (MRI) studies, abnormalities of brain structure and resting-state connectivity were demonstrated in patients with long-term remission of CD. However, no data are available on functional alteratio...

Background: Patients with Cushing’s Syndrome (CS) suffer from a variety of neuropsychiatric and cognitive problems. Following remission, some, but not all of these symptoms resolve. Recent cross-sectional studies in patients with CS show persistent structural and functional brain abnormalities. However, longitudinal studies using magnetic resonance imaging, and a detailed neurocognitive assessment, performed before and after treatment, are not available.<p class="abs...